Synthetic Pot:NotYour Grandfather’s Marijuana
20 de Fevereiro de 2017
In theearly2000sinEuropeandshortlythereafterintheUSA,itwasreported
that ‘legal’ forms ofmarijuanawerebeingsoldunderthenameK2and/orSpice.
Active ingredientsinK2/Spiceproductsweredeterminedtobesynthetic
cannabinoids (SCBs),producingpsychotropicactionsviaCB1 cannabinoid
receptors, similartothoseof D9-tetrahydrocannabinol (D9-THC), theprimary
active constituentinmarijuana.Oftenabusedbyadolescentsandmilitary
personnel toeludedetectionindrugtestsduetotheirlackofstructural
similarity to D9-THC, SCBsarefalselymarketedassafemarijuanasubstitutes.
Instead, SCBsareahighlystructuraldiversegroupofcompounds,easily
synthesized, whichproduceverydangerousadverseeffectsoccurringby,
as ofyet,unknownmechanisms.Therefore,availableevidenceindicatesthat
K2/Spice productsareclearlynotsafemarijuanaalternatives.
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