Artigos científicos
Opioid agonist treatment Guiding principles for legislation and regulations
Foreword In the United States, 12 prosecutors have been tasked with identifying doctors and pharmacists throughout the country who prescribe or dispense medicines containing opioids without any regard as to how they are to be used. At the same time, the uncontrolled use of opioids has caused a new spate of fatalities in North America, which is in the throes of a real public health crisis. Why is the United States undergoing such a crisis? What can Europe do to avoid it?
Informe 2018
La publicación del informe de la Junta Internacional de Fiscalización de Estupefacientes (JIFE) correspondiente a 2018 marca el cincuentenario de la creación de la Junta, de conformidad con la Convención Única de 1961 sobre Estupefacientes1.
A randomised,double-blind,placebo-controlled, efficacy studyofnalmefene,as-neededuse,in patients withalcoholdependence
Abstract Thisstudyevaluatedtheefficacy ofas-neededuseoftheopioid systemmodulatornalmefenein reducingalcoholconsumptioninpatientswithalcoholdependence.Sevenhundredandeighteen patients(placebo=360;nalmefene=358), ≥18yearsofage,withadiagnosisofalcoholdependence, ≥6 heavydrinkingdaysandanaveragealcoholconsumption ≥WHO mediumdrinkingrisklevelinthe 4 weeksprecedingscreening,wererandomised(1:1)to24weeksofas-neededplaceboornalmefene 18 mg/day.
Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: A 1-year, randomised controlled study
Abstract This study evaluated the long-term efficacy and safety of nalmefene treatment in reducing alcohol consumption. We randomised (1:3) 675 alcoholdependent patients ≥ 18 years of age to 52 weeks of as-needed treatment with placebo or nalmefene 18 mg/day: A total of 112 patients (68%) in the placebo group and 310 (62%) in the nalmefene group completed the study. At
Extending the Treatment Options in Alcohol Dependence: A Randomized Controlled Study of As-Needed Nalmefene
Background: There is a large treatment gap in alcohol dependence, and current treatments are only moderately effective in preventing relapse. New treatment modalities, allowing for reduction of alcohol consumption as a treatment goal are needed. This study evaluated the efficacy of as-needed use of the opioid system modulator nalmefene in reducing alcohol consumption in patients with alcohol dependence.
Neuropsychological Performance in Polyconsumer Men Under Treatment. Influence of Age of Onset of Substance Use
Neurocognition is a key factor in the development and maintenance of Substance Use Disorders (SUD). However, there are still several aspects that need to be studied in this area.
Differential neurophysiological correlates of information processing in Internet gaming disorder and alcohol use disorder measured by event-related potentials
Internet gaming disorder (IGD) shares clinical and neuropsychological features with alcohol use disorder (AUD), but few studies have identified the neurophysiological characteristics of IGD.
Delta coherence in resting-state EEG predicts the reduction in cigarette craving after hypnotic aversion suggestions
Cigarette craving is a key contributor of nicotine addiction. Hypnotic aversion suggestions have been used to help smoking cessation and reduce smoking relapse rates but its neural basis is poorly understood.
Dissociable Effects of Cocaine Dependence on Reward Processes: The Role of Acute Cocaine and Craving
INTRODUCTION Approximately 14% of Americans aged 12 years and over report lifetime cocaine use, with ~ 1million individuals experiencing cocaine use disorder/dependence (CUD) in the United States (SAMHSA, 2014).
