Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments
06 de Outubro de 2017
INTRODUCTION
Addiction and related impulse control disorders have an estimated cost to society of 600 billion
dollars per year (1). In humans, substance abuse varies with current drug availability trends and sex
differences are reported (2), but the direction of those differences is not always consistent, as it varies
with current trends in substance availability and cost (3). However, in recent years, women exceed
men in the abuse of prescription drugs, men use more alcohol and stimulant drugs than women, and
the use of nicotine has been more equal across sexes (4). By contrast, animal studies have revealed
more consistent trends in drug-seeking behavior indicating that females are more likely to initiate
and maintain drug-seeking behavior, and they have a better response to treatment than males.
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