Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences
Cannabis and tobacco are frequently used together, identifying
their individual associations on mental health
is difficult but important, as this can advance understanding
of causal mechanisms and help target preventive
interventions.
Individualswhouse cannabis regularly have a 2- to 3-fold
increased risk of a psychotic outcome.1 Tobacco use is also associatedwith
an increased incidence of psychotic disorders2-5
in cohort studies, and (less consistently)with subclinical psychoticsymptoms,
6-8withhypothesized casualmechanismsincluding
nicotine increasing dopamine release and inducingD2-
receptor supersensitivity.5,9
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