Genetic Predisposition vs Individual-Specific Processes in the Association Between Psychotic-like Experiences and Cannabis Use
IMPORTANCE Previous research indicates that cannabis use is associated with psychotic-like
experiences (PLEs). However, it is unclear whether this association results from
predispositional (ie, shared genetic) factors or individual-specific factors (eg, causal
processes, such as cannabis use leading to PLEs).
OBJECTIVES To estimate genetic and environmental correlations between cannabis use and
PLEs, and to examine PLEs in twin and nontwin sibling pairs discordant for exposure to
cannabis use to disentangle predispositional from individual-specific effects.
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