Effect of Cannabidiol on Medial Temporal, Midbrain, and StriatalDysfunction inPeople at Clinical High Risk of Psychosis A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE Cannabidiol may partially normalize alterations in
parahippocampal, striatal, and midbrain function associated with the CHR state. As these
regions are critical to the pathophysiology of psychosis, the influence of CBD at these sites
could underlie its therapeutic effects on psychotic symptoms.
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